ESI MS studies highlight the selective interaction of Auranofin with protein free thiols
Carlotta Zoppi, Luigi Messori, Alessandro Pratesi
Abstract
The study of the mode-of-action of Auranofin, a cytotoxic gold(<sc>i</sc>) compound, reveals that it binds exclusively to the free and solvent-accessible cysteine residues of biologically relevant proteins.
Topics & Concepts
AuranofinChemistryCysteineCombinatorial chemistryMode of actionGold CompoundsProtein–protein interactionStereochemistryBiochemistryBiologyEnzymeRheumatoid arthritisImmunologyTrace Elements in HealthMetal complexes synthesis and propertiesNanocluster Synthesis and Applications