A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis
Jian-Kui Du, Qing Yu, Yujian Liu, Shufang Du, Li-Yang Huang, Dan‐Hong Xu, Xin Ni, Xiaoyan Zhu
Abstract
The present findings uncovered a novel pro-EndMT mechanism during the pathogenesis of diabetic cardiac fibrosis via the upregulation of KLK8, and may contribute to the development of future KLK8-based therapeutic strategies for diabetic cardiomyopathy.
Topics & Concepts
PathogenesisKallikreinFibrosisCardiac fibrosisMedicineDiabetes mellitusChemistryInternal medicineCell biologyBiologyEndocrinologyBiochemistryEnzymeCoagulation, Bradykinin, Polyphosphates, and AngioedemaPeptidase Inhibition and AnalysisGDF15 and Related Biomarkers