Antidiabetic activity and acute toxicity of combined extract of Andrographis paniculata, Syzygium cumini, and Caesalpinia sappan
Eem Masaenah, Berna Elya, Heri Setiawan, Zahra Fadhilah, Febrika Wediasari, Gumilar Adhi Nugroho, Elfahmi Elfahmi, Tjandrawati Mozef
Abstract
< 0.05), but not triglycerides, compared to diabetic control, this effect was comparable to metformin treatment. In addition, the pancreatic β-cells numbers were likely increased after ASCE treatment in a dose-dependent manner. The oral administration of a single dose of ASCE was safe up to 5000 mg/kg BW and did not result in any significant difference in body weight, relative organ weight, hematological and biochemical parameters compared with the control group. Therefore, it can be concluded that ASCE has a potential antidiabetic effect and can be safely developed as alternative medicine.
Topics & Concepts
Andrographis paniculataSyzygiumMetforminTraditional medicineStreptozotocinAcute toxicityMedicineDiabetes mellitusBody weightPharmacologyToxicityInternal medicineEndocrinologyPathologyAlternative medicineAndrographolide Research and ApplicationsPhytochemicals and Medicinal Plants