Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors
Hee Jin Jeong, Hye Lim Lee, Sung Joon Kim, Jeong Hyun Jeong, Su Hyun Ji, Han Byeol Kim, Miso Kang, Hwan Won Chung, Chan Sun Park, Hyunah Choo, Hyo Jae Yoon, Nam‐Jung Kim, Duck‐Hyung Lee, Sang‐Hee Lee, Seo‐Jung Han
Abstract
causes inhibition of tumour growth in 4T1 syngeneic mouse model. This study provides new insight into the designing of novel ENPP1 inhibitors and warrants further development of small molecule immune modulators for cancer immunotherapy.
Topics & Concepts
Stimulator of interferon genesStingPhosphodiesteraseIC50Cancer immunotherapyChemistrySmall moleculeInterferonImmune systemPharmacologyImmunotherapyBiochemistryBiologyIn vitroEnzymeGeneticsCytosolAerospace engineeringEngineeringinterferon and immune responsesCytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases