Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management
Xu Chen, Jiapan Shen, Xueqin Jiang, Min Pan, Shuang Chang, Juanjuan Li, Lei Wang, Manli Miao, Xiaoxia Feng, Ling Zhang, Guoqing Shu, Wenjian Liu, Fangzhou Xu, Wentao Zhang, Zhao Ding, Huaiyuan Zong, Weiwei Liu, Dapeng Li, Biao Chen, Min Shao, Guanghe Fei, Xiaojun Zha, Xiaoyun Fan
Abstract
: These findings provide compelling evidence that DIPY inhibits ferroptosis in pulmonary epithelial and endothelial cells by modulating the SOD1/CREB1/HMOX1 signaling axis and suggest DIPY as a promising therapeutic strategy for ARDS treatment.
Topics & Concepts
Acute respiratory distressDipyridamoleMedicineRespiratory distressRespiratory systemIntensive care medicinePharmacologyCardiologyInternal medicineLungAnesthesiaFerroptosis and cancer prognosisMicroRNA in disease regulationCircular RNAs in diseases