Oxidative [3+2] Annulation of Pyridinium Salts with <i>gem</i>‐Difluoroalkenes: Synthesis of 2‐Fluoroindolizines
Li‐Miao Yang, You‐Ya Zhang, Jing‐Tong Deng, Ai‐Jun Ma, Xiang‐Zhi Zhang, Shu‐Yu Zhang, Jin‐Bao Peng
Abstract
Abstract An oxidative [3+2] annulation of pyridinium salts with gem ‐difluoroalkenes for the synthesis of highly substituted 2‐fluoroindolizines has been developed. Using DBU as base, a broad range of multisubstituted 2‐fluoroindolizines were prepared in good to excellent yields under mild conditions, and many useful functional groups can be tolerated.
Topics & Concepts
PyridiniumAnnulationChemistryOxidative phosphorylationCombinatorial chemistryOrganic chemistryBase (topology)Medicinal chemistryCatalysisBiochemistryMathematicsMathematical analysisSynthesis and Reactivity of HeterocyclesFluorine in Organic ChemistryCyclopropane Reaction Mechanisms