Chemically Tuning the Antigen Release Kinetics from Spherical Nucleic Acids Maximizes Immune Stimulation
Kacper Skakuj, Michelle H. Teplensky, Shuya Wang, Jasper W. Dittmar, Chad A. Mirkin
Abstract
, increasing the rate of antigen release resulted in higher T cell activation and target killing. These findings provide fundamental insights into and underscore the importance of vaccine structure.
Topics & Concepts
AntigenAdjuvantImmune systemIn vivoChemistryLinkerIn vitroPeptideT cellEx vivoCell biologyBiochemistryMolecular biologyBiophysicsBiologyImmunologyBiotechnologyOperating systemComputer scienceImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques