Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1
Julien Rossignol, Zakia Belaid, Guillemette Fouquet, Flavia Guillem, Rachel Rignault, Pierre Milpied, Amédée Renand, Téreza Coman, Maud D’Aveni, Michaël Dussiot, Elia Colin, Jonathan Lévy, Caroline Carvalho, Nicolas Goudin, Nicolas Cagnard, Francine Côté, Joël Babdor, Kanit Bhukhai, Laura Polivka, Amélie Bigorgne, Heloise M. Halse, Aurélien Marabelle, Séverine Mouraud, Yves Lepelletier, Thiago Trovati Maciel, Marie‐Thérèse Rubio, Delphine Héron, Caroline Robert, Isabelle Girault, Doris Lebeherec, Jean‐Yves Scoazec, Ivan Cruz Moura, Louise Condon, Mirjana Weimershaus, Franck Pagès, Jean Davoust, David‐Alexandre Gross, Olivier Hermine
Abstract
T cells predicts poor outcome of patients treated with anti-PD1. NRP1 is a promising target to overcome resistance to anti-PD1 therapies.