Reduced pannexin 1–IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients
Hao Li, Xiaoyu Yu, Baojie Shi, Kun Zhang, Liyun Yuan, Xueni Liu, Pusen Wang, Junwei Lv, Guangxun Meng, Qiankun Xuan, Wenjuan Wu, Bin Li, Xiao Peng, Xuebin Qin, Wanqing Liu, Lin Zhong, Zhihai Peng
Abstract
= 0.011) ameliorated MRSA infection and animal death. Reduced human hepatic IL-33 protein abundance also associated with increased predisposition to MRSA infection. Our findings reveal that genetic predisposition to reduced PANX1 function increases risk for MRSA infection after liver transplantation by decreasing hepatic host innate immune defense, which can be attenuated by IL-33 treatment.
Topics & Concepts
Innate immune systemMedicineImmunityPannexinImmunologyImmune systemBiologyGap junctionConnexinIntracellularCell biologyIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisImmune Cell Function and Interaction