Mutation Profile of Over 4500 SARS-CoV-2 Isolations Reveals Prevalent Cytosine-to-Uridine Deamination on Viral RNAs
Yue Li, Xinai Yang, Na Wang, Haiyan Wang, Bin Yin, Xiaoping Yang, Wenqing Jiang
Abstract
The excessive C-T mismatches do not resemble the random mutation profile. They are likely to be caused by the cytosine-to-uridine deamination system in hosts.
Topics & Concepts
DeaminationCytosineVirologyUridineBiologyMutationRNAGeneticsDNAGeneEnzymeBiochemistryCRISPR and Genetic EngineeringViral Infections and Immunology Researchinterferon and immune responses