Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC
Daiki Ikarashi, Tamio Okimoto, Takehito Shukuya, Hiroko Onagi, Takuo Hayashi, Sara L. Sinicropi-Yao, Joseph M. Amann, Tetsuya Nakatsura, Shigehisa Kitano, David P. Carbone
Abstract
INTRODUCTION: This study investigates the immune profile of the primary lung tumors and the corresponding brain metastasis from patients with NSCLC using multiplex fluorescence immunohistochemistry. METHODS: The study evaluated 34 patients who underwent autopsy or surgical resection for brain metastasis and autopsy, surgical resection, or core biopsy for primary lung cancer. We compared the densities of various immune cells in the primary tumors and the brain metastases by multiplex fluorescence immunohistochemical analysis. RESULTS: = 0.0173). CONCLUSIONS: T-cells was higher in cancer and stroma areas of brain metastases after radiotherapy supports the addition of immunotherapy to radiation therapy in the treatment of brain metastases in NSCLC.