Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent <i>ex vivo</i> photovasodilation
Naoya Ieda, Yuka Yoshikawa, Natsumi Tomita, Kei Ohkubo, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa
Abstract
We found that N -nitrosoaminoanisole derivatives tethered to dyes work as photocontrollable nitrosonium cation releasers and are converted to potent nitric oxide releasers in the presence of sodium ascorbate.
Topics & Concepts
ChemistryNitric oxideEx vivoSodiumIn vivoInorganic chemistryPhotochemistryOrganic chemistryIn vitroBiochemistryBiologyBiotechnologyPhotochromic and Fluorescence ChemistryOxidative Organic Chemistry ReactionsNanoplatforms for cancer theranostics