Anti-SARS-CoV-2 Potential of Artemisinins In Vitro
Ruiyuan Cao, Hengrui Hu, Yufeng Li, Xi Wang, Mingyue Xu, Jia Liu, Huanyu Zhang, Yunzheng Yan, Lei Zhao, Wei Li, Tianhong Zhang, Dian Xiao, Xiaojia Guo, Yuexiang Li, Jingjing Yang, Zhìhóng Hú, Manli Wang, Wu Zhong
Abstract
of 23.17 ± 3.22 μM was not prominent among the tested compounds, lumefantrine showed therapeutic promise due to high plasma and lung drug concentrations after multiple dosing. Further mode of action analysis revealed that arteannuin B and lumefantrine acted at the post-entry step of SARS-CoV-2 infection. This research highlights the anti-SARS-CoV-2 potential of artemisinins and provides leading candidates for anti-SARS-CoV-2 drug research and development.
Topics & Concepts
DihydroartemisininArtemisininArtesunateLumefantrinePharmacologyDrugArtemetherMedicinePharmacokineticsPharmacodynamicsMalariaPlasmodium falciparumImmunologyComputational Drug Discovery MethodsMalaria Research and ControlSARS-CoV-2 and COVID-19 Research