Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction
Axelle Bois, Catarina Grandela, James Gallant, Christine L. Mummery, Philippe Menasché
Abstract
Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This review explores strategies for heart regeneration, offers insights into cardiomyocyte proliferation, evaluates in vivo models, and discusses integrating in vitro human cardiac models to advance cardiac regeneration research.
Topics & Concepts
Myocardial infarctionRegeneration (biology)CardiologyMedicineInternal medicineHeart failureIntensive care medicineBiologyCell biologyCongenital heart defects researchTissue Engineering and Regenerative MedicineCardiac Fibrosis and Remodeling