Scaling DNA data storage with nanoscale electrode wells
Bichlien H. Nguyen, Christopher N. Takahashi, Gagan Gupta, Jake A. Smith, Richard Rouse, Paul Berndt, Sergey Yekhanin, David Ward, Siena Dumas Ang, Patrick Garvan, Hsing-Yeh Parker, Robert H. Carlson, Douglas M. Carmean, Luís Ceze, Karin Strauß
Abstract
sequences per square centimeter, three orders of magnitude improvement over existing DNA synthesis arrays. We show confinement of DNA synthesis to an area under 1 square micrometer, parallelized over millions of nanoelectrode wells and then successfully write and decode a message in DNA. DNA synthesis on this scale will enable write throughputs to reach megabytes per second and is a key enabler to a practical DNA data storage system.
Topics & Concepts
Computer scienceComputer data storageKey (lock)NanotechnologyDNAThroughputDNA sequencingComputer hardwareMaterials scienceBiologyWirelessTelecommunicationsGeneticsComputer securityAdvanced biosensing and bioanalysis techniquesDNA and Biological ComputingElectrowetting and Microfluidic Technologies