GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure
Jinqiu Tao, Cailin Xue, Xiaodong Wang, Huihui Chen, Qiaoyu Liu, Chunping Jiang, Wenjie Zhang
Abstract
Collectively, our findings suggest that GAS1 overexpression plays a key role in aggravating APAP-induced acute liver injury by promoting ferroptosis-induced accumulation of lipid peroxides.
Topics & Concepts
AcetaminophenDownregulation and upregulationApoptosisGPX4Liver injuryLipid peroxideProgrammed cell deathReactive oxygen speciesCell growthChemistryCellGlutathioneCell biologyLipid peroxidationPharmacologyBiologyGeneOxidative stressBiochemistryEnzymeGlutathione peroxidaseFerroptosis and cancer prognosisCancer, Lipids, and MetabolismDrug Transport and Resistance Mechanisms