Novel amino‐Li resin for water‐based solid‐phase peptide synthesis
Christina Uth, Simon Englert, Olga Avrutina, Harald Kolmar, Sascha Knauer
Abstract
We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides.
Topics & Concepts
Peptide synthesisSolid-phase synthesisPeptideAmino acidCombinatorial chemistryAqueous solutionChemistryPhase (matter)Organic chemistryBiochemistryChemical Synthesis and AnalysisClick Chemistry and ApplicationsBiochemical and Structural Characterization