Design, synthesis, and evaluation of 1,2,3‐triazole‐based benzenesulfonamide and flavonol hybrid molecules as anticancer agents
Yu‐Xun Chen, Chuan‐Hsin Chang, Caiwei Li, Jih‐Jung Chen, Tzenge‐Lien Shih
Abstract
Abstract Background The design and synthesis of hybrid molecules will explore finding new drugs. Objectives The synthesized hybrid molecules to evaluate their biological properties. Methods Apply click chemistry to tether flavonols and benzenesulfonamide. Results Two drug candidates show potential against lung cancer. Conclusions Two drug candidates did not affect the normal cells and provided a new drug design route.
Topics & Concepts
ChemistryFlavonolsDrugCombinatorial chemistryMoleculeTriazolePharmacologyBiochemistryOrganic chemistryFlavonoidMedicineAntioxidantClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisSynthesis and biological activity