HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages
Shulin Zhao, Rongrong Zhao, Chuanzheng Wang, Caizhi Ma, Zijie Gao, Boyan Li, Yanhua Qi, Wei Qiu, Ziwen Pan, Shaobo Wang, Qindong Guo, Jiawei Qiu, Yang Fan, Xiaofan Guo, Hao Xue, Lin Deng, Gang Li
Abstract
Our findings revealed the role of the novel HDAC7-H3K27ac-SOX8/JUN-LGALS3-ITGB1 axis in maintaining the crosstalk between MES GBM and M2 MDM, highlighting that HDAC7 and LGALS3 may serve as potential prognostic biomarkers and therapeutic targets in GBM.
Topics & Concepts
CrosstalkMesenchymal stem cellGlioblastomaCancer researchCell biologyCancer cellChemistryNeuroscienceBiologyMedicineCancerInternal medicineEngineeringElectronic engineeringHistone Deacetylase Inhibitors ResearchCancer-related gene regulationPeptidase Inhibition and Analysis