Affinity ultrafiltration and UPLC-HR-Orbitrap-MS based screening of thrombin-targeted small molecules with anticoagulation activity from Poecilobdella manillensis
Qiuyang Huang, Jianyuan Tang, Xiaoxin Chai, Wei Ren, Jiabo Wang, Qichao Gan, Jingyan Shi, Manyuan Wang, Sijin Yang, Jingfang Liu, Li Ma
Topics & Concepts
ChemistryOrbitrapChromatographyThrombinDiscovery and development of direct thrombin inhibitorsUltrafiltration (renal)Small moleculeHigh-performance liquid chromatographyMass spectrometryBiochemistryPlateletImmunologyBiologyLeech Biology and ApplicationsVenomous Animal Envenomation and StudiesHealthcare and Venom Research