A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements
James L. Wood, Saikat Ghosh, Zachary H. Houston, Nicholas L. Fletcher, James Humphries, Karine Mardon, Dewan Taslima Akhter, William Tieu, Alesia Ivashkevich, Michael Wheatcroft, Kristofer J. Thurecht, Rachel Codd
Abstract
Lu]Lu-DOTA-mAb, both showing a sustained reduction in tumour volume (>80% over 65 d) compared to vehicle. The work identifies D2 as a trifunctional chelator that could expand capabilities in mixed-element radiometal theranostics to improve dosimetry and the clinical outcomes of molecularly targeted radiation.
Topics & Concepts
DOTAChelationPairingDual (grammatical number)Combinatorial chemistryChemistryNanotechnologyMaterials scienceOrganic chemistryPhysicsLiteratureQuantum mechanicsSuperconductivityArtRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsMedical Imaging and Pathology Studies