Caveolin-mediated cytosolic delivery of spike nanoparticle enhances antitumor immunity of neoantigen vaccine for hepatocellular carcinoma
Zhiwen Lin, Chenwei Jiang, Peiyuan Wang, Qingjing Chen, Bing Wang, Xinyue Fu, Yuzhi Liang, Da Zhang, Yongyi Zeng, Xiaolong Liu
Abstract
Overall, the developed novel spike nanoparticles with efficient neoantigen and adjuvant intracellular delivery capability holds great promise for future clinical translation to improve HCC immunotherapy.
Topics & Concepts
Cancer researchTumor microenvironmentTLR9CD8MedicineMetastasisImmune systemHepatocellular carcinomaImmunotherapyImmunologyCancerBiologyInternal medicineDNA methylationGeneBiochemistryGene expressionImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryT-cell and B-cell Immunology