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Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li‐Huei Tsai

2022Cell stem cell287 citationsDOIOpen Access PDF

Topics & Concepts

MicrogliaBiologyPremovement neuronal activityApolipoprotein ENeuroscienceExtracellularInduced pluripotent stem cellDiseaseCell biologyGeneImmunologyInflammationInternal medicineGeneticsMedicineEmbryonic stem cellNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsCholesterol and Lipid Metabolism
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity | Litcius