Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity
Nancy J. Ames, Jennifer J. Barb, Kornel E. Schuebel, Sarah Mudra, Brianna Meeks, Ralph Thadeus S. Tuason, Alyssa T. Brooks, Narjis Kazmi, Shanna Yang, Kelly Ratteree, Nancy Diazgranados, Michael Krumlauf, Gwenyth R. Wallen, David Goldman
Abstract
= .02). The VHD drinking group displayed greater change from baseline. The Shannon diversity index of the gut microbiome changed significantly during abstinence in five participants. In both groups, the Shannon diversity was lower in the oral microbiome than gut. Ten total genera were shared between oral and stool in the AUD participants. These data were compared with healthy controls from the Human Microbiome Project to investigate the concept of a core microbiome. Rapid changes in gut microbiome following abstinence from alcohol suggest resilience of the gut microbiome in AUD and reflects the benefits of refraining from the highest levels of alcohol and potential benefits of abstinence.