Stabilized cyclic peptides as modulators of protein–protein interactions: promising strategies and biological evaluation
Jiongjia Cheng, Junlong Zhou, Lingyan Kong, Hai‐Ying Wang, Yuchi Zhang, Xiaofeng Wang, Guang‐Xiang Liu, Qian Chu
Abstract
development of cyclic peptide ligands with pharmacological properties. In summary, the development of cyclic peptide-based PPI modulators carries tremendous promise for the next generation of therapeutic agents to target historically "intractable" PPI systems.
Topics & Concepts
Cyclic peptideComputational biologyPeptideSmall moleculeChemistryPeptidomimeticDrug discoveryCell permeabilityProtein–protein interactionBiologyBiochemistryChemical Synthesis and AnalysisClick Chemistry and ApplicationsBiochemical and Structural Characterization