Rapid, quantitative and ultra-sensitive detection of cancer biomarker by a SERRS-based lateral flow immunoassay using bovine serum albumin coated Au nanorods
Luchun Lu, Jiangliu Yu, Xiaoxian Liu, Xingsheng Yang, Zihui Zhou, Qing Jin, Rui Xiao, Chongwen Wang
Abstract
. By comparison, the detection limit of the proposed assay is about 100 and 10 times lower than those of the Au nanoparticle-based SERS-strip and conventional enzyme-linked immunosorbent assay, respectively. Moreover, the potential clinical applications of the assay were evaluated by detecting 10 actual serum samples. Results showed 100% accuracy based on the clinical tests.
Topics & Concepts
Detection limitBovine serum albuminImmunoassayChemistryNanorodChromatographyRaman scatteringAlbuminClinical diagnosisRaman spectroscopyNanotechnologyMaterials scienceAntibodyBiochemistryImmunologyMedicinePhysicsClinical psychologyOpticsAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and ApplicationsBiosensors and Analytical Detection