Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells
Ji Hoon Kim, Caitlin D. Hanlon, Sunaina Vohra, Peter N. Devreotes, Deborah J. Andrew
Abstract
, and dPIP5K. Smoothened also localizes with F-actin at the migration front, and Hh, through Smo, increases levels of Tre1 at the plasma membrane and Tre1's association with dPIP5K.
Topics & Concepts
SmoothenedCell biologyBiologyActinHedgehogG protein-coupled receptorUpstream and downstream (DNA)Hedgehog signaling pathwayGerm cellSignal transductionGeneticsGeneComputer scienceComputer networkUpstream (networking)Cellular transport and secretionDevelopmental Biology and Gene RegulationGenomics and Chromatin Dynamics