Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from <i>Aspergillus burnettii</i>
Indra Roux, Simon Bowles, John A. Kalaitzis, Daniel Vuong, Ernest Lacey, Yit‐Heng Chooi, Andrew M. Piggott
Abstract
Burnettiene A is a novel cytotoxic tridecaketide decalin polyketide from Aspergillus burnettii . Its biosynthesis was elucidated by heterologous expression in fungi.
Topics & Concepts
PolyketidePolyeneHeterologousAspergillusBiosynthesisHeterologous expressionDecalinBiologyMicrobiologyChemistryBiochemistryEnzymeGeneRecombinant DNACatalysisMicrobial Natural Products and BiosynthesisPlant Pathogens and Fungal DiseasesFungal Biology and Applications