Gut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy
Ji Eun Kim, Hoonsik Nam, Ji In Park, Hyunjeong Cho, Jangwook Lee, Hyoeun Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong Soo Kim, Sunghyouk Park, Hajeong Lee
Abstract
Whole metagenomic sequencing uncovered specific members of the gut microbiota associated with DMN. The gene families derived from the discovered species are involved in the metabolic pathways of methionine and branched-chain amino acids. Metabolomic analysis using stool samples showed increased methionine and branched-chain amino acids in DMN. These integrative omics results provide evidence of the gut microbiota-associated pathophysiology of DMN, which can be further studied for disease-modulating effects via prebiotics or probiotics.
Topics & Concepts
MethionineAmino acidMetagenomicsGeneBiologyBiochemistryMetabolismGeneticsGut microbiota and healthDiet and metabolism studiesMetabolism and Genetic Disorders