The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor
Jennifer Q. Zhang, Benedikt Bosbach, Jennifer K. Loo, Gerardo A. Vitiello, Shan Zeng, Adrian M. Seifert, Benjamin D. Medina, Nesteene J. Param, Joanna H. Maltbaek, Ferdinand Rossi, Cristina R. Antonescu, Peter Besmer, Ronald P. DeMatteo
Topics & Concepts
Cancer researchBiologySunitinibImatinibProto-Oncogene Proteins c-kitInterstitial cell of CajalMutationGiSTStromal tumorStromal cellCarcinogenesisTyrosine-kinase inhibitorCD117Tyrosine kinaseCancerImmunologyCD34Signal transductionGeneticsStem cell factorHaematopoiesisImmunohistochemistryGeneStem cellMyeloid leukemiaGastrointestinal Tumor Research and TreatmentGastric Cancer Management and OutcomesGastrointestinal disorders and treatments