A One Health approach for the genomic surveillance of AMR
Veronica M. Jarocki, Max L. Cummins, Celeste M. Donato, Benjamin P. Howden, Steven P. Djordjevic
Abstract
In the face of an escalating antimicrobial resistance (AMR) crisis, genomic technologies have emerged as indispensable allies, providing innovative tools for a nuanced understanding of the abundance, persistence and mobilisation of antimicrobial resistance genes within microbial populations. This article explores advancements in genomic surveillance, including the integration with advanced computational tools to enhance our ability to predict AMR trends, detect outbreaks, and inform mitigation strategies. It highlights the critical role of a One Health approach, emphasising the importance of cross-sectoral collaboration among scientists, health care professionals, industry and policymakers to leverage genomic data for AMR management. The article showcases pioneering initiatives in Australia, such as the Melbourne Genomics Alliance’s Controlling Superbugs Clinical Flagship, the Australian Centre for Genomic Epidemiological Microbiology and AusTrakka, and discusses the need to both build global genomic databases that promote equitable analytics, and secure data-sharing platforms that support comprehensive surveillance networks. Through national and international collaborative efforts, One Health genomic surveillance represents a key strategy in enhancing our understanding and control of AMR and should be integrated into public health frameworks to safeguard against ever emerging AMR threats.