Rh-catalyzed regio-switchable cross-coupling of <i>gem</i>-difluorinated cyclopropanes with allylboronates to structurally diverse fluorinated dienes
Yaxin Zeng, Hui Yang, Jiayi Du, Qin Huang, Guoliang Huang, Ying Xia
Abstract
-difluorinated cyclopropanes and allylboronates. The controlled terminal/internal regioselectivity arises from the fine-tuning of the rhodium catalytic system. Fluorinated 1,3-dienes, 1,4-dienes and 1,5-dienes are therefore produced in good yields with respectively isomerized terminal, internal, and terminal regioselectivity.
Topics & Concepts
RegioselectivityChemistryCatalysisTerminal (telecommunication)RhodiumSelectivityCoupling (piping)Combinatorial chemistryOrganic chemistryMaterials scienceMetallurgyComputer scienceTelecommunicationsCyclopropane Reaction MechanismsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions