The memory B cell response to influenza vaccination is impaired in older persons
Alice R. Burton, Stéphane M. Guillaume, William S. Foster, Adam K. Wheatley, Danika L. Hill, Edward J Carr, Michelle A. Linterman
Abstract
atypical memory B cells can derive from germinal center (GC) precursors. Together, this study shows that the aged human GC reaction and memory B cell response following vaccination is defective.
Topics & Concepts
Memory B cellGerminal centerSomatic hypermutationVaccinationImmunologyB cellHemagglutinin (influenza)BiologyMedicineVirologyAntibodyT-cell and B-cell ImmunologyImmune Cell Function and InteractionSingle-cell and spatial transcriptomics