Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa <i>In Vitro</i> and <i>In Vivo</i>
Dina A. Moustafa, Ashley Wallace, Danniel Zamora, Seth M. Daly, Carolyn R. Sturge, Christine Pybus, Bruce L. Geller, Joanna B. Goldberg, David E. Greenberg
Abstract
Numerous Gram-negative bacteria are becoming increasingly resistant to multiple, if not all, classes of existing antibiotics. Multidrug-resistant Pseudomonas aeruginosa bacteria are a major cause of health care-associated infections in a variety of clinical settings, endangering patients who are immunocompromised or those who suffer from chronic infections, such as people with cystic fibrosis (CF).
Topics & Concepts
MorpholinoIn vivoPseudomonas aeruginosaIn vitroMultiple drug resistanceChemistryConjugated systemPeptideMicrobiologyBiologyBiochemistryBacteriaAntibioticsZebrafishGeneticsGenePolymerOrganic chemistryAntimicrobial Peptides and ActivitiesAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatment