A Selective and Reversible Fluorescent Probe for Zn <sup>2+</sup> Detection in Living Cells
Xin Chen, Yufan Ma, Yuanyuan Zhang, Qing Chen, Hongmei Wang, Zhuo Wang
Abstract
Abstract A newly 8‐aminoquioline based fluorescent probe ( NQA ) was designed and synthesized as a good turn‐on fluorescence sensor to reversibly detect Zn 2+ . The probe can detect Zn 2+ in an aqueous solution with good selectivity without interference from other metal ions (Cd 2+ in particular). And the limit of detection was calculated to be 2.15×10 −9 M. The probe can efficiently monitor the change of concentration of Zn 2+ in a broad pH range from 4.0 to 11.0. NQA can detection of Zn 2+ reversibly based on the coordination interaction. NQA is biocompatibility and can be used to monitor the concentration of Zn 2+ in living cells without the interference from other similar cations, especially Cd 2+ .