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The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress

So Masaki, Kozue Hashimoto, Daiki Kihara, Chizuru Tsuzuki, Naoyuki Kataoka, Kenji Suzuki

2020Biochemical and Biophysical Research Communications31 citationsDOI

Topics & Concepts

PKM2Allosteric regulationTetramerChemistryBiochemistryPyruvate kinaseAlternative splicingWarburg effectCell biologyGlycolysisGene isoformEnzymeBiologyGeneCancer, Hypoxia, and MetabolismRNA modifications and cancerRNA Research and Splicing
The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress | Litcius