Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid–base equilibria
Žiko Milanović, Marko Antonijević, Ana Amić, Edina Avdović, Dušan Dimić, Dejan Milenković, Zoran Marković
Abstract
Identification of potential inhibitory effect of acid–base species of quercetin and its metabolite as well as chloroquine, hydroxychloroquine, and cinanserin, at physiological pH, on proteins essential for SARS-CoV-2 virus survival.
Topics & Concepts
QuercetinMetaboliteInhibitory postsynaptic potentialEnzymeChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)IC50Active metaboliteCoronavirus disease 2019 (COVID-19)PharmacologyBiochemistryBiologyMedicineIn vitroInfectious disease (medical specialty)DiseaseAntioxidantPathologyNeuroscienceComputational Drug Discovery MethodsVitamin C and Antioxidants ResearchDrug-Induced Hepatotoxicity and Protection