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A simple Ag–MoS<sub>2</sub> hybrid nanozyme-based sensor array for colorimetric identification of biothiols and cancer cells

Yin Li, Yumeng Liu, Y. ZHANG, Mengmeng Dong, Lidong Cao, Kai Jiang

2024RSC Advances16 citationsDOIOpen Access PDF

Abstract

nanozyme was correlated with the pH of the reaction solution and the inhibitory effects of the three biothiols on the nanozyme-triggered chromogenic system differed in the specific pH environments. Therefore, each sensing unit of this electronic tongue generated differential colorimetric fingerprints of different biothiols. After principal component analysis (PCA), the developed novel colorimetric sensor array can accurately discriminate biothiols between different types, various concentrations, and different mixture proportions. Further, the sensor array was used for the colorimetric identification of real serum and cellular samples, demonstrating its great potential in tumor diagnostic applications.

Topics & Concepts

ChemistryIntracellularBiomarkerIdentification (biology)CancerCancer cellNanotechnologyCancer researchBiochemistryMaterials scienceMedicineBiologyInternal medicineBotanyAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesElectrochemical sensors and biosensors