Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
Jing Li, Changyu Qiu, Yue-Jin Tao, Lei Cheng
Abstract
Chronic rhinosinusitis (CRS) has brought a huge socioeconomic burden. However, its mechanism is still elusive, which may involve genetic, environmental and some other factors. Epigenetic analyses have been conducted to explore the mechanisms underlying CRS. Here, we reviewed the fruits in the epigenetic studies on DNA methylation, histone modification, and non-coding RNA regulation. We concluded that the epigenetic research on CRS has made great breakthroughs, especially in the past 5 years and the field of microRNAs. "Epigenetic therapies" are expected to be designed to treat CRS in the future.
Topics & Concepts
Nasal polypsChronic rhinosinusitisEpigeneticsMedicineBiologyGeneticsInternal medicineGeneSinusitis and nasal conditionsNasal Surgery and Airway StudiesAllergic Rhinitis and Sensitization