Design, synthesis, and evaluation of antitumor activity of Mobocertinib derivatives, a third-generation EGFR inhibitor
Dang Fan, Han Zhang, Lei Duan, Long Li, Shan Xu, Yuanbiao Tu, Linxiao Wang, Pengwu Zheng, Wufu Zhu
Topics & Concepts
ChemistryT790MIn vitroLead compoundIC50KinaseApoptosisCell growthIn vivoStereochemistryStructure–activity relationshipCell cyclePharmacologyBiochemistryEpidermal growth factor receptorReceptorBiologyBiotechnologyGefitinibLung Cancer Treatments and MutationsPI3K/AKT/mTOR signaling in cancerCancer therapeutics and mechanisms