A review: silicate ceramic-polymer composite scaffold for bone tissue engineering
Mohsen Ahmadipour, Hossein Mohammadi, Ai Ling Pang, Mohammad Arjmand, Tunmise Ayode Otitoju, Patrick U. Okoye, Beerelli Rajitha
Abstract
Bone tissue engineering is one of the vital approaches used to tackle bone defects in the past decades. This approach is a risk-free alternative to conventional bone graft substitutes, such as autografts, allografts, and xenografts. Silicate bioceramics have improved mechanical properties and biological performances compared with phosphate-based ceramics. However, their brittleness limits their application in load-bearing sites. Therefore, silicate-based ceramics have been used in combination with several polymers in the form of a composite scaffold. This review article summarizes the influence of silicate ceramics on the mechanical, cytocompatibility, and bioactivity of polymeric-based scaffold for bone tissue engineering application.