Oral administration of egg ovalbumin allergen induces dysregulation of tryptophan metabolism in sensitized BALB/c mice
Zhongliang Wang, Jie Zhang, Jinbo Yuan, Fangfang Min, Jinyan Gao, Wenfeng Liu, Meijia Huang, Yong Wu, Hongbing Chen
Abstract
. Additionally, disruption of the tryptophan indole derivative pathway compromises the maintenance of intestinal mucosal function through the AHR signaling pathway, manifested by decreased expression of Reg3g and IL22. Taken together, this study demonstrated that the anaphylaxis triggered by oral ingestion of food allergens can lead to disruptions in tryptophan metabolism, consequently impairing intestinal immune homeostasis.
Topics & Concepts
OvalbuminAllergenBALB/cImmunologyOral administrationChemistryTryptophanMetabolismBiologyPharmacologyAllergyAntigenImmune systemBiochemistryAmino acidFood Allergy and Anaphylaxis ResearchDermatology and Skin DiseasesAllergic Rhinitis and Sensitization