Gold nanorod-based multiplex bioanalytical assay for the detection of CYFRA 21-1 and CA-125: towards oral cancer diagnostics
Debolina Chakraborty, Amitava Mukherjee, K. R. Ethiraj
Abstract
. The individual GNR bioprobe also showed high specificity against several interferents. For multiplexed biosensing, the plasmon spectra of the GNR bioprobe mixture showed distinct responses upon binding of single and dual targets in the sample mixture and/or artificial saliva. The quantitative data from the developed method are of high clinical significance that can aid in the understanding of clinicopathological advancements in oral cancer at an early stage. This simple yet novel nanosized optical transducer technology can be further converted into miniaturized biochips and can be deployed in clinics as a nanoparticle-based point-of-care diagnostic adjunct.
Topics & Concepts
BioanalysisMultiplexCancerNanorodChemistryCancer researchNanotechnologyMolecular biologyChromatographyMedicineMaterials scienceInternal medicineBiologyBioinformaticsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionAdvanced Biosensing Techniques and Applications