Rejuvenating the Activity of Usual Antibiotics on Resistant Gram-Negative Bacteria: Recent Issues and Perspectives
Jinane Tabcheh, Julia Vergalli, Anne Davin‐Regli, Noha Ghanem, Jean‐Marie Pagès, Charbel Al-Bayssari, Jean Michel Brunel
Abstract
Antibiotic resistance continues to evolve and spread beyond all boundaries, resulting in an increase in morbidity and mortality for non-curable infectious diseases. Due to the failure of conventional antimicrobial therapy and the lack of introduction of a novel class of antibiotics, novel strategies have recently emerged to combat these multidrug-resistant infectious microorganisms. In this review, we highlight the development of effective antibiotic combinations and of antibiotics with non-antibiotic activity-enhancing compounds to address the widespread emergence of antibiotic-resistant strains.
Topics & Concepts
AntibioticsAntibiotic resistanceAntimicrobialMultiple drug resistanceBiologyMicrobiologyIntensive care medicineGram-negative bacteriaMedicineGeneticsEscherichia coliGeneAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsBacterial biofilms and quorum sensing