Palladium-catalysed site-selective arene <i>ortho</i> C–H fluoroalkoxylation of 4-aryl-pyrrolo[2,3-<i>d</i>]pyrimidines
Yunfeng Jiang, Chenhong Pan, Ting Tang, Mingrui Liu, Xingxian Zhang
Abstract
A series of mono- and bis-fluoroalkoxylated compounds of 4-aryl-pyrrolo[2,3- d ]pyrimidine derivatives were synthesized by Pd-catalysed direct C–H fluoroalkoxylation in a mild, efficient and highly site selective manner.
Topics & Concepts
PalladiumPyrimidineChemistryArylCatalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions