Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance
Heng Fang, Miaoxian Fang, Yirong Wang, Huidan Zhang, Jiaxin Li, Jingchun Chen, Qingrui Wu, Linling He, Jing Xu, Jia Deng, Mengting Liu, Yiyu Deng, Chunbo Chen
Abstract
The role of gut microbiota in the pathophysiology of sepsis is gaining increasing attention and developing effective and safe sepsis therapies targeting intestinal microorganisms is promising. Given the safety of probiotic supplementation or fecal microbiota transplantation in critically ill patients, identifying an abiotic agent to regulate the intestinal microbiota of septic patients is of clinical significance.
Topics & Concepts
SepsisGut floraDysbiosisBiologyMicrobiologyFecesImmunologyTransplantationProbioticBacteriaMedicineInternal medicineGeneticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disorders