Modular Design of High-Brightness pH-Activatable Near-Infrared BODIPY Probes for Noninvasive Fluorescence Detection of Deep-Seated Early Breast Cancer Bone Metastasis: Remarkable Axial Substituent Effect on Performance
Peng Wu, Yu Zhu, Senyao Liu, Hu Xiong
Abstract
) allowed the successful targeting and visualization of deep-seated bone metastases of breast cancer with a high tumor to normal contrast of 8/1, outperforming X-rays in early detection. This strategy may provide insights for designing high-brightness activatable NIR probes for detecting deep-seated tumors and metastases.
Topics & Concepts
FluorescenceIn vivoChemistryBreast cancerFluorescence-lifetime imaging microscopyMaterials scienceMetastasisBrightnessBiophysicsCancerPhotochemistryMedicineOpticsBiologyInternal medicinePhysicsBiotechnologyNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques