Ca2+ signaling in T lymphocytes: the interplay of the endoplasmic reticulum, mitochondria, membrane potential, and CRAC channels on transcription factor activation
Pei‐Chi Yang, M. Saleet Jafri
Abstract
and modulates the activation of CRAC channels. Furthermore, the model simulations explain how the complex interaction of the endoplasmic reticulum, membrane potential, mitochondria, and ion channels such as CRAC channels control T cell activation.
Topics & Concepts
Endoplasmic reticulumCell biologyIntracellularCalcium signalingTranscription factorSTIM1MitochondrionChemistryStimulationCalcium in biologyReceptorBiologyBiochemistryNeuroscienceGeneIon Channels and ReceptorsCalcium signaling and nucleotide metabolismSignaling Pathways in Disease