Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and <i>in vivo</i> modeling
Salma A. Fereig, Ghada M. El-Zaafarany, Mona G. Arafa, Mona M.A. Abdel-Mottaleb
Abstract
results on imiquimod (IMQ)-induced mouse model showed promising anti-psoriatic effects upon application of gold conjugated tacrolimus-loaded lecithin-chitosan hybrid nanoparticles with a significant difference from the bare hybrid nanoparticles in some of the inflammatory markers. The anti-inflammatory effect of the gold conjugate was also evident by a lower spleen to body weight ratio and a better histopathological skin condition compared to other tested formulations.
Topics & Concepts
Colloidal goldMaterials scienceNanoparticleIn vivoChitosanZeta potentialSelected area diffractionLecithinParticle sizeConjugateDynamic light scatteringNuclear chemistryNanotechnologyTransmission electron microscopyChemistryChromatographyOrganic chemistryPhysical chemistryMathematicsBiologyBiotechnologyMathematical analysisAdvancements in Transdermal Drug DeliveryPsoriasis: Treatment and PathogenesisNigella sativa pharmacological applications