MicroRNA-139-5p upregulation is associated with diabetic endothelial cell dysfunction by targeting c-jun
Yufang Luo, Xin-xing Wan, Liling Zhao, Zi Guo, Rui-Ting Shen, Pingyu Zeng, Ling-Hao Wang, Jingjing Yuan, Wenjun Yang, Chun Yue, Zhaohui Mo
Abstract
experiments (Matrigel plug assay and hindlimb ischemia model) showed that miR-139-5p downregulation further promoted ECFC-mediated angiogenesis and blood perfusion. In conclusion, diabetes-mediated high miR-139-5p expression inhibits the c-jun-VEGF/PDGF-B pathway, thus decreasing ECFCs migration, tube formation and proliferation, which subsequently reduces ECs survival. Therefore, miR-139-5p might be an important therapeutic target in the treatment of diabetic vasculopathy in the future.
Topics & Concepts
Downregulation and upregulationmicroRNAc-junCancer researchMedicineEndothelial dysfunctionBiologyInternal medicineGeneTranscription factorGeneticsAngiogenesis and VEGF in CancerElectrospun Nanofibers in Biomedical ApplicationsMesenchymal stem cell research